Podophyllotoxin - Southern Herbals Limited

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Southern Herbals Limited

**PHYSICAL PROPERTIES**
RAW MATERIAL	Rhizome and roots of Podophyllum emodi wall (Bebendacae)
PREPARATION	Total extractives using solvent, selective extraction, further processing and purification.
PHYSICAL CHARACTERISTICS	White Crystalline Powder and very hygroscopic mp 110-116 deg. C soluble in Chloroform-dried mp 177-182 deg. C

**CHEMICAL CHARACTERISTICS**
COMMON NAMES	Podophyllotoxin, Podofilox, Condyline, Condylox, Wartec, Warticon.
CHEMICAL NAME	(5R-(5a, 5ab, 8aa 9a)-5,8,8a,9-Tetrahytro-9-hydroxy-5{3,4,5-trimethoxyphenyl) furo ( 3’4’6’7) napththo(2,3-d)-1,3-dioxol-6(5aH)-one
MOLECULAR FORMULA	C22 H22 08
MOLECULAR WEIGHT	414.40
IDENTIFICATION IR (KBr) UV (Max) Specific optical rotation	V max 1760, 1592, 1240 cm 292 nm Between -129.0 -136.3 (Chloroform)
PURITY (HPLC)	95% plus as specified.
TOXICITY	Highly Toxic
USE	Antineoplastic activity, in treatment if warts, Raw material for Etoposide and Teniposide.