Southern Herbals Limited

Manufacturer of Fine Chemicals

Vincristine Sulfate Vinblastine Sulfate Teniposide Etoposide Paclitaxel
Podophyllotoxin Camptothecine Baccatin III 10-Deacetybaccatin III Colchicine
Belomycin* Doxorubicin* Capsaicin Forskolin Ajmalicine
  Sennosides Glymnemic Acid    

 ETOPOSIDE

PHYSICAL PROPERTIES
 RAW MATERIAL Podophyllotoxin & 4’ demethylpodophyllotoxin.
PREPARATION Synthesis.
 PHYSICAL CHARACTERISTICS White Crystalline Compound; mp  236-251 deg C  Soluble in Chloroform.
CHEMICAL CHARACTERISTICS 
COMMON NAMES Etoposide: EPEG; NSC-141540: VP -16-213; Lastet; Vepesid
CHEMICAL NAME 9-[( 4,6-0-Ethylidene-b-D- glucopyranosyl) oxy] -5,8,8a,9-teetrahydro 5-(4-hydroxy-3,5-dimethoxyphenyl)furo(3’,4’6,7] naptho[2,3-d]-1, 3-dioxol-6(5aH]-one
MOLECULAR FORMULA C29 H32 013 
MOLECULAR WEIGHT 588.56
IDENTIFICATION 
Specific Optical rotation

-110.5 deg     (Chloroform)
PURITY  HPLC 96%
USE Anti cancer, Refractory testicular tumors, Small cell iung Cancer.  The Predominant effect of etoposide is inhibation of DNA Synthesis resulting in arrest of cell cycle. At high  doses  cells entering mitosis are lysed.
PROPRITARY NAMES AND MANUFACTURERS Vumon (BMS), Lastet ( Nippon Hayaku)

Etoposide Etoposide Etoposide Etoposide Etoposide Etoposide Etoposide Etoposide Etoposide Etoposide
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