CHEMICAL
CHARACTERISTICS
| COMMON NAMES |
Colchicine (natural) |
| CHEMICAL NAME |
N-(5,6,7-9
Tetrahydro-1,2,310-tetramethoxy-9-Oxobenzo(a)
haptelen-7-yl) acetamide. |
| MOLECULAR FORMULA |
C22 H25 NO6 |
| MOLECULAR WEIGHT |
399.43 |
IDENTIFICATION
IR (KBr)
UV |
1660, 1610, 1555 & 1495 cm- 1
350.5, 243 nm |
| PURITY |
By HPLC 97% plus as specified. |
| TOXICITY |
Highly Toxic |
| ACTION & USE |
Used in treatment of gout, cancer. It
apparently exerts its effect by reducing the inflammatory
response to the deposited urate crystals and also by
diminishing phagocytosis. Deposition of urate is
favoured by acid pH environment by inhibiting lactic acid
production by leucocytes, thereby interrupting urate
deposition and inflammatory response that sustains the
acute attack. |
